N-nucleotides

{
  "id": "MLC-T-CHM-007975",
  "term": "N-nucleotides",
  "field": "Chemistry",
  "definition": "Nucleotides that are randomly added to the junctions between gene segments during the somatic recombination of T-cell receptor and immunoglobulin genes. This process, mediated by terminal deoxynucleotidyl transferase (TdT), increases the diversity of antigen receptors. The addition of N-nucleotides contributes significantly to junctional diversity, which is a key mechanism for generating a vast repertoire of immune specificities.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T-cell receptor",
    "diversity gene",
    "joining gene",
    "variable gene"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1218 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/n-nucleotides/"
}