Junctional diversity

{
  "id": "MLC-T-CHM-006292",
  "term": "Junctional diversity",
  "field": "Chemistry",
  "definition": "A mechanism for generating variability in the antigen-binding sites of immunoglobulin and T-cell receptors during lymphocyte development. It occurs through the imprecise joining of Variable (V), Diversity (D), and Joining (J) gene segments. The enzyme terminal deoxynucleotidyl transferase (TdT) adds non-templated nucleotides at these junctions, further increasing the sequence variation.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T-cell receptor",
    "diversity gene",
    "heavy chain",
    "joining gene",
    "variable gene"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1198 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/junctional-diversity/"
}