N-region

{
  "id": "MLC-T-CHM-008089",
  "term": "N-region",
  "field": "Chemistry",
  "definition": "A segment of DNA encoding the non-templated nucleotides (N-nucleotides) inserted at the junctions of rearranged V, D, and J gene segments in immunoglobulin and T-cell receptor genes. This region is generated by the enzyme terminal deoxynucleotidyl transferase during lymphocyte development. It contributes to the vast diversity of antigen-binding sites.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "heavy chain",
    "variable region"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1218 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/n-region/"
}