Gene rearrangement

{
  "id": "MLC-T-CHM-004813",
  "term": "Gene rearrangement",
  "field": "Chemistry",
  "definition": "A cellular process that alters the sequence of DNA by cutting, shuffling, and joining gene segments to create new genetic combinations. This mechanism is a hallmark of the adaptive immune system, where it generates the vast diversity of antigen receptors on B and T lymphocytes. The process involves specific enzymes, such as RAG recombinases, that recognize and splice V (variable), D (diversity), and J (joining) gene segments.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T-cell receptor",
    "immunology",
    "variable region"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1169 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/gene-rearrangement/"
}