Vα-Jα rearrangement

{
  "id": "MLC-T-CHM-012496",
  "term": "Vα-Jα rearrangement",
  "field": "Chemistry",
  "definition": "A genetic recombination process occurring during T-cell development in the thymus, where variable (V) and joining (J) gene segments of the T-cell receptor alpha chain are brought together. This rearrangement creates a unique antigen-binding site, contributing to the diversity of T-cell receptors. It is a key step in adaptive immunity.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T-cell receptor"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1257 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/va-ja-rearrangement/"
}