V(D)J recombination

{
  "id": "MLC-T-CHM-012532",
  "term": "V(D)J recombination",
  "field": "Chemistry",
  "definition": "A somatic recombination process that randomly assembles gene segments encoding the variable regions of T cell receptors and immunoglobulins. This genetic rearrangement occurs in developing lymphocytes, specifically B and T cells, to generate a vast repertoire of antigen-binding specificities. The process involves variable (V), diversity (D), and joining (J) gene segments.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "B lymphocyte",
    "diversity gene",
    "joining gene",
    "T lymphocyte",
    "variable gene",
    "heavy chain",
    "light chain",
    "recombination-activating gene",
    "somatic recombination"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1258 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/v-d-j-recombination/"
}