Recombination signal sequence

{
  "id": "MLC-T-CHM-010023",
  "term": "Recombination signal sequence",
  "field": "Chemistry",
  "definition": "Specific DNA sequences flanking the variable (V), diversity (D), and joining (J) gene segments in immunoglobulin and T-cell receptor loci. These sequences are recognized by the recombination-activating gene (RAG) enzymes, initiating V(D)J recombination. Each sequence consists of a conserved heptamer and nonamer, separated by a 12-base pair or 23-base pair spacer.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T-cell receptor",
    "antigen receptor",
    "lymphocyte"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1239 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/recombination-signal-sequence/"
}