Germinal center

{
  "id": "MLC-T-CHM-004864",
  "term": "Germinal center",
  "field": "Chemistry",
  "definition": "A specialized microenvironment within secondary lymphoid organs, such as lymph nodes and the spleen, where B lymphocytes proliferate, undergo somatic hypermutation, and affinity maturation. This process leads to the generation of high-affinity antibody-producing plasma cells and memory B cells. Germinal centers are transient structures that form in response to T-cell dependent antigen stimulation.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "B lymphocyte",
    "lymph node",
    "maturation",
    "memory",
    "spleen"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1169 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/germinal-center/"
}