Primary lymphoid follicle

{
  "id": "MLC-T-CHM-009433",
  "term": "Primary lymphoid follicle",
  "field": "Chemistry",
  "definition": "A dense, spherical aggregation of B lymphocytes found in lymphoid organs such as lymph nodes and the spleen, prior to antigen exposure. These follicles lack a germinal center and consist mainly of naive B cells. Upon antigenic stimulation, a primary follicle can develop into a secondary lymphoid follicle with a germinal center.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "B lymphocyte",
    "germinal center",
    "lymphoid follicle",
    "secondary lymphoid tissue"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1234 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/primary-lymphoid-follicle/"
}