anti-CD133-CAR vector-transduced allogeneic T lymphocytes

{
  "id": "MLC-T-ONC-010228",
  "term": "anti-CD133-CAR vector-transduced allogeneic T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic peripheral blood T lymphocytes (PBTL) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the chimeric CD (cluster of differentiation) 133 antigen receptor, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD133-CAR vector-transduced allogeneic T lymphocytes specifically recognize and kill CD133-expressing tumor cells. CD133, a tumor associated antigen (TAA), is overexpressed on a variety of tumor cell types.",
  "synonyms": [
    "allogeneic CART133",
    "allogeneic anti-CD133 CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd133-car-vector-transduced-allogeneic-t-lymphocytes/"
}