autologous anti-Muc1/CD33/CD38/CD56/CD123 gene-engineered CAR-T cells

{
  "id": "MLC-T-ONC-011483",
  "term": "autologous anti-Muc1/CD33/CD38/CD56/CD123 gene-engineered CAR-T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of genetically modified autologous T cells transduced with lentiviral vectors expressing chimeric antigen receptors (CARs) specific for the tumor-associated antigens (TAAs) mucin 1 (Muc1; MUC1), cluster of differentiation 33 (CD33), CD38, CD56 and CD123 (interleukin-3 receptor alpha chain or IL3RA), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-Muc1/CD33/CD38/CD56/CD123 gene-engineered CAR-T cells are directed to and induce selective toxicity in Muc1/CD33/CD38/CD56/CD123-expressing tumor cells. Muc1/CD33/CD38/CD56/CD123 are present on certain tumor cell types and are minimally expressed on normal, healthy cells. Expression of these TAAs are correlated with poor prognosis. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules included in the CARs, are required for full T-cell activation and enhance both proliferation of T cells and antitumor activity.",
  "synonyms": [
    "autologous Muc1/CD33/CD38/CD56/CD123-specific gene-engineered CAR-T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-muc1-cd33-cd38-cd56-cd123-gene-engineered-car-t-cells/"
}