NGFR-transduced autologous T lymphocytes

{
  "id": "MLC-T-ONC-015500",
  "term": "NGFR-transduced autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous, genetically modified T lymphocytes that are expressing the tumor-associated antigen (TAA) nerve growth factor receptor (NGFR; p75 neurotrophin receptor; p75(NTR); CD271), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the NGFR-transduced autologous T lymphocytes may induce an immune response and may kill NGF-expressing tumor cells. Dysregulated NGF signaling may promote proliferation and invasion in certain tumor cell types.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ngfr-transduced-autologous-t-lymphocytes/"
}