Rintodestrant

{
  "id": "MLC-T-ONC-016551",
  "term": "Rintodestrant",
  "field": "Oncology and biomedicine",
  "definition": "An orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, rintodestrant specifically targets and binds to the estrogen receptor alpha (ERalpha; ERa; ESR1) and induces a conformational change that promotes ERalpha degradation and downregulation. This prevents ERalpha-mediated signaling and inhibits both the growth and survival of ERalpha-expressing cancer cells.",
  "synonyms": [
    "selective estrogen receptor downregulator G1T48",
    "selective estrogen receptor degrader G1T48"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/rintodestrant/"
}