Neutral loss scan

{
  "id": "MLC-T-CHM-007909",
  "term": "Neutral loss scan",
  "field": "Chemistry",
  "definition": "A mass spectrometry scanning mode where the mass spectrometer detects all precursor ions that undergo a specific neutral mass loss upon fragmentation. Both the first and second mass analyzers are scanned synchronously, maintaining a constant mass difference between them. This technique is particularly effective for identifying compounds that share a common substructure or functional group, such as the loss of water (18 Da) or carbon dioxide (44 Da).",
  "subject": "Analytical Chemistry",
  "see_also": [
    "constant neutral mass loss spectrum"
  ],
  "references": [
    "PAC, 2013, 85, 1515. 'Definitions of terms relating to mass spectrometry (IUPAC Recommendations 2013)' on page 1572 (https://doi.org/10.1351/PAC-REC-06-04-06)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/neutral-loss-scan/"
}