Perforin

{
  "id": "MLC-T-CHM-013381",
  "term": "Perforin",
  "field": "Chemistry",
  "definition": "A pore-forming protein released by cytotoxic T lymphocytes and natural killer cells. This protein inserts into the membrane of target cells, creating channels that allow granzymes to enter and induce apoptosis. Perforin is a key effector molecule in the immune system's defense against virally infected cells and tumor cells.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "cytotoxic T lymphocyte",
    "natural killer cell",
    "target cell"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1226 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/perforin/"
}