Alkylating agent

{
  "id": "MLC-T-CHM-000403",
  "term": "Alkylating agent",
  "field": "Chemistry",
  "definition": "A chemical compound that transfers an alkyl group to another molecule, often a biological macromolecule like DNA or protein. These agents can form covalent bonds with nucleophilic sites on these molecules, leading to structural and functional changes. Many alkylating agents are used in chemotherapy due to their ability to damage DNA and inhibit cell proliferation.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1164 (https://doi.org/10.1351/pac200779071153)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/alkylating-agent/"
}