Electron-transfer/higher-energy collision dissociation

{
  "id": "MLC-T-CHM-003766",
  "term": "Electron-transfer/higher-energy collision dissociation",
  "field": "Chemistry",
  "definition": "A hybrid fragmentation technique in mass spectrometry that combines electron-transfer dissociation (ETD) with higher-energy collision dissociation (HCD). This method first applies ETD to generate c- and z-type ions, and then subjects these primary fragments to HCD to produce further fragmentation. The combination yields a richer set of fragment ions, including b- and y-type ions, providing more sequence information for complex peptides.",
  "subject": "Analytical Chemistry",
  "see_also": [
    "electron-transfer dissociation",
    "higher-energy collision dissociation"
  ],
  "references": [
    "PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1155 (https://doi.org/10.1515/pac-2016-1120)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/electron-transfer-higher-energy-collision-dissociation/"
}