Higher-energy collision dissociation

{
  "id": "MLC-T-CHM-005289",
  "term": "Higher-energy collision dissociation",
  "field": "Chemistry",
  "definition": "A beam-type collision-induced dissociation technique, implemented mainly in Orbitrap (Kingdon trap) instruments, in which precursor ions are accelerated into a multipole collision cell and fragmented by energetic collisions with neutral gas. Unlike resonance-excitation CID in an ion trap, it has no low mass cut-off, so low-mass reporter ions such as tandem mass tag fragments are detected.",
  "subject": "Analytical Chemistry",
  "see_also": [
    "proteomics"
  ],
  "references": [
    "PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1156 (https://doi.org/10.1515/pac-2016-1120)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/higher-energy-collision-dissociation/"
}