Protein fragmentation

{
  "id": "MLC-T-CHM-013446",
  "term": "Protein fragmentation",
  "field": "Chemistry",
  "definition": "The cleavage of a protein into smaller pieces. In tandem mass spectrometry of intact proteins, as in top-down proteomics, it is the dissociation of protein ions by methods such as collision-induced, electron-capture or electron-transfer dissociation, which yields fragment ions that carry sequence information. Cleavage with proteases or chemical reagents before analysis is called proteolysis.",
  "subject": "Analytical Chemistry",
  "see_also": [
    "peptide fragment ion",
    "top-down proteomics"
  ],
  "references": [
    "PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1161 (https://doi.org/10.1515/pac-2016-1120)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/protein-fragmentation/"
}