Top-down proteomics

{
  "id": "MLC-T-CHM-012109",
  "term": "Top-down proteomics",
  "field": "Chemistry",
  "definition": "A strategy in proteomics that involves the analysis of intact proteins without prior proteolytic digestion. This approach directly measures the mass and sequence of whole proteins, providing information on post-translational modifications and protein isoforms. It typically requires high-resolution mass spectrometry for accurate characterization of large biomolecules.",
  "subject": "Analytical Chemistry",
  "see_also": [
    "bottom-up proteomics"
  ],
  "references": [
    "PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1165 (https://doi.org/10.1515/pac-2016-1120)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/top-down-proteomics/"
}