Hydrogen/deuterium exchange

{
  "id": "MLC-T-CHM-005472",
  "term": "Hydrogen/deuterium exchange",
  "field": "Chemistry",
  "definition": "A method in mass spectrometry where labile hydrogen atoms in a molecule are replaced by deuterium atoms. This exchange is typically performed by exposing the sample to a deuterated solvent or atmosphere. The mass increase due to deuterium incorporation provides information about the number of exchangeable protons and the solvent accessibility of different parts of the molecule.",
  "subject": "Analytical Chemistry",
  "references": [
    "PAC, 2013, 85, 1515. 'Definitions of terms relating to mass spectrometry (IUPAC Recommendations 2013)' on page 1547 (https://doi.org/10.1351/PAC-REC-06-04-06)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/hydrogen-deuterium-exchange/"
}