Immunoreceptor tyrosine-based inhibitory motif

{
  "id": "MLC-T-CHM-005703",
  "term": "Immunoreceptor tyrosine-based inhibitory motif",
  "field": "Chemistry",
  "definition": "A conserved amino acid sequence found in the cytoplasmic tails of certain inhibitory immune receptors, such as those on natural killer cells and B lymphocytes. Upon receptor engagement, these motifs become phosphorylated on tyrosine residues, recruiting phosphatases that counteract activating signals. This leads to the suppression of immune cell activation.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "natural killer cell"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1191 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/immunoreceptor-tyrosine-based-inhibitory-motif/"
}