Killer activatory receptor

{
  "id": "MLC-T-CHM-006333",
  "term": "Killer activatory receptor",
  "field": "Chemistry",
  "definition": "A cell surface receptor expressed on natural killer (NK) cells that, upon binding to its ligand, triggers an activating signal for the NK cell. These receptors recognize stress-induced ligands or altered major histocompatibility complex (MHC) class I molecules on target cells. Activation leads to the release of cytotoxic granules and cytokines, initiating target cell lysis.",
  "synonyms": [
    "killer cell immunoglobulin-like receptor"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "C-type lectin",
    "killer cell immunoglobulin-like receptor",
    "immunoreceptor tyrosine-based activation motif",
    "immunoreceptor tyrosine-based inhibitory motif",
    "killer cell",
    "major histocompatibility complex class I molecule",
    "natural killer cell",
    "α:β T cell",
    "γ:δ T cell"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1198 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/killer-activatory-receptor/"
}