CD16

{
  "id": "MLC-T-CHM-001762",
  "term": "CD16",
  "field": "Chemistry",
  "definition": "A low-affinity Fc receptor for immunoglobulin G (IgG), also known as FcγRIII, expressed on natural killer (NK) cells, macrophages, and neutrophils. This receptor mediates antibody-dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of IgG antibodies coating target cells. CD16 exists in two isoforms, CD16a (transmembrane) and CD16b (glycosylphosphatidylinositol-anchored).",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "Fc receptor",
    "antibody-dependent cellular cytotoxicity",
    "macrophage",
    "natural killer cell"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1139 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/cd16/"
}