Antibody-dependent cellular cytotoxicity

{
  "id": "MLC-T-CHM-000665",
  "term": "Antibody-dependent cellular cytotoxicity",
  "field": "Chemistry",
  "definition": "A mechanism of immune defense where target cells coated with antibodies are recognized and lysed by certain immune effector cells. These effector cells, such as natural killer cells, bind to the Fc region of the antibodies. This binding triggers the release of cytotoxic substances, leading to the destruction of the target cell.",
  "synonyms": [
    "antibody-dependent cell-mediated cytotoxicity"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "cytotoxic",
    "Fc receptor",
    "natural killer cell",
    "eosinophil",
    "leukocyte",
    "macrophage",
    "neutrophil",
    "target cell"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1123 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/antibody-dependent-cellular-cytotoxicity/"
}