Janus-family tyrosine kinase

{
  "id": "MLC-T-CHM-006281",
  "term": "Janus-family tyrosine kinase",
  "field": "Chemistry",
  "definition": "A family of intracellular non-receptor tyrosine kinases that associate with cytokine receptors and are activated upon ligand binding. These enzymes phosphorylate specific tyrosine residues on the receptor and downstream signaling molecules, initiating intracellular signaling cascades. Four members of this family, JAK1, JAK2, JAK3, and TYK2, are known in mammals.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "JAK/STAT signaling pathway",
    "tyrosine kinase",
    "cytokine"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1197 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/janus-family-tyrosine-kinase/"
}