Mitogen-activated protein kinase

{
  "id": "MLC-T-CHM-007419",
  "term": "Mitogen-activated protein kinase",
  "field": "Chemistry",
  "definition": "A family of serine/threonine-specific protein kinases that respond to extracellular stimuli and regulate cellular processes including proliferation, differentiation, and apoptosis. These enzymes are activated through a tiered signaling cascade involving a MAP kinase kinase kinase (MAP3K) and a MAP kinase kinase (MAP2K). The three major subfamilies in mammals are the extracellular signal-regulated kinases (ERKs), the c-Jun N-terminal kinases (JNKs), and the p38 MAP kinases.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1213 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/mitogen-activated-protein-kinase/"
}