Mammalian target of rapamycin

{
  "id": "MLC-T-CHM-006943",
  "term": "Mammalian target of rapamycin",
  "field": "Chemistry",
  "definition": "A serine/threonine protein kinase that integrates signals from nutrients, growth factors, and cellular energy status to control processes like cell proliferation, protein synthesis, and autophagy. This enzyme is a central regulator of metabolism and physiology in mammals. The immunosuppressive drug rapamycin (sirolimus) and its derivatives function by forming a complex that inhibits the activity of this kinase.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "immunosuppressive"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1209 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/mammalian-target-of-rapamycin/"
}