Zeta chain-associated protein kinase-70 kDa

{
  "id": "MLC-T-CHM-012807",
  "term": "Zeta chain-associated protein kinase-70 kDa",
  "field": "Chemistry",
  "definition": "A tyrosine kinase enzyme expressed in T lymphocytes and natural killer cells that is integral to initiating T-cell receptor signaling. Upon T-cell activation, this protein, abbreviated as ZAP-70, is recruited to the receptor complex where it phosphorylates downstream adaptors, leading to a signaling cascade. Mutations in the gene encoding ZAP-70 can cause a form of severe combined immunodeficiency in humans.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T lymphocyte",
    "lymphocyte activation",
    "tyrosine kinase"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1261 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/zeta-chain-associated-protein-kinase-70-kda/"
}