Mitophagy

{
  "id": "MLC-T-CHM-013294",
  "term": "Mitophagy",
  "field": "Chemistry",
  "definition": "The selective degradation of mitochondria through the process of autophagy, a cellular quality control mechanism. This process removes damaged or dysfunctional mitochondria to maintain cellular health and prevent the accumulation of reactive oxygen species. Mitophagy is initiated by the accumulation of proteins like PINK1 on the outer mitochondrial membrane, which then recruits the E3 ubiquitin ligase Parkin to tag the organelle for engulfment by an autophagosome.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "autophagy"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1213 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/mitophagy/"
}