Leffler’s relation

{
  "id": "MLC-T-CHM-006511",
  "term": "Leffler’s relation",
  "field": "Chemistry",
  "definition": "An empirical linear relation between the changes in Gibbs energy of activation and the changes in standard Gibbs energy of reaction across a series of related elementary reactions, with slope alpha. The slope, usually between 0 and 1, measures how closely the transition state resembles the products, and it underlies the Leffler-Hammond view that strongly exergonic steps have early, reactant-like transition states.",
  "synonyms": [
    "Leffler’s assumption"
  ],
  "subject": "Organic and Biomolecular Chemistry",
  "references": [
    "PAC, 2022, 94, 353. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 2021)' on page 453 (https://doi.org/10.1515/pac-2018-1010)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/lefflers-relation/"
}