Nuclear Overhauser effect difference spectroscopy

{
  "id": "MLC-T-CHM-008110",
  "term": "Nuclear Overhauser effect difference spectroscopy",
  "field": "Chemistry",
  "definition": "A nuclear magnetic resonance (NMR) technique that highlights signals enhanced by the nuclear Overhauser effect (NOE) by subtracting two spectra. One spectrum is acquired with selective saturation of a specific resonance, and the other is a control spectrum without saturation. The resulting difference spectrum shows only the NOE-enhanced signals, providing clear evidence of spatial proximity between nuclei.",
  "synonyms": [
    "nOe difference spectroscopy"
  ],
  "subject": "Analytical Chemistry",
  "see_also": [
    "nuclear magnetic resonance spectrum",
    "nuclear Overhauser effect"
  ],
  "references": [
    "PAC, 2021, 93, 647. 'Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019)' on page 698 (https://doi.org/10.1515/pac-2019-0203)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/nuclear-overhauser-effect-difference-spectroscopy/"
}