Nucleic acid aptamers

Term · Chemistry · MLC-T-CHM-008129

Short single-stranded DNA or RNA molecules that fold into defined three-dimensional shapes and bind a chosen target, from small molecules to proteins, with high affinity and selectivity. They are found by an in vitro selection cycle called SELEX, in which a large random library is repeatedly bound, separated and amplified. Unlike antibodies, they are made by chemical synthesis rather than in living cells, so batches do not vary biologically.

Table 1. Record
Identifier	MLC-T-CHM-008129
Field	Chemistry
Subject	Analytical Chemistry
References	PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1148 (https://doi.org/10.1515/pac-2016-1120)

Record as JSON

{
  "id": "MLC-T-CHM-008129",
  "term": "Nucleic acid aptamers",
  "field": "Chemistry",
  "definition": "Short single-stranded DNA or RNA molecules that fold into defined three-dimensional shapes and bind a chosen target, from small molecules to proteins, with high affinity and selectivity. They are found by an in vitro selection cycle called SELEX, in which a large random library is repeatedly bound, separated and amplified. Unlike antibodies, they are made by chemical synthesis rather than in living cells, so batches do not vary biologically.",
  "subject": "Analytical Chemistry",
  "references": [
    "PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1148 (https://doi.org/10.1515/pac-2016-1120)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/nucleic-acid-aptamers/"
}

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