Specific binding

{
  "id": "MLC-T-CHM-011099",
  "term": "Specific binding",
  "field": "Chemistry",
  "definition": "The reversible interaction between a ligand and a macromolecule, such as a protein or nucleic acid, that occurs at a defined binding site with high affinity and selectivity. This interaction is characterized by its saturability and competition with other specific ligands. Non-specific binding, in contrast, involves lower affinity interactions at multiple sites.",
  "subject": "Analytical Chemistry",
  "see_also": [
    "nucleotide sequence"
  ],
  "references": [
    "PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1186 (https://doi.org/10.1515/pac-2016-1120)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/specific-binding/"
}