Cooperativity

{
  "id": "MLC-T-CHM-002554",
  "term": "Cooperativity",
  "field": "Chemistry",
  "definition": "A phenomenon observed in multi-subunit enzymes or proteins where the binding of a ligand to one active site influences the binding affinity of subsequent ligands to other active sites. This can lead to either positive cooperativity, where binding increases affinity, or negative cooperativity, where it decreases affinity. Hemoglobin's oxygen binding exhibits positive cooperativity.",
  "subject": "Chemistry and the Environment",
  "see_also": [
    "allosteric enzymes",
    "binding site",
    "conformation",
    "enzymes",
    "substrate"
  ],
  "references": [
    "PAC, 1992, 64, 143. 'Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)' on page 151 (https://doi.org/10.1351/pac199264010143)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/cooperativity/"
}