Ligand efficiency

Term · Chemistry · MLC-T-CHM-006567

A metric used in drug discovery to assess the binding affinity of a ligand to its target protein, normalized by the size or complexity of the ligand. It provides a way to compare compounds of different molecular weights or numbers of heavy atoms. This value is often expressed as binding energy per heavy atom or per unit molecular weight.

Table 1. Record
Identifier	MLC-T-CHM-006567
Field	Chemistry
Subject	Chemistry and Human Health
References	PAC, 2016, 88, 239. 'Glossary of terms used in computational drug design, part II (IUPAC Recommendations 2015)' on page 249 (https://doi.org/10.1515/pac-2012-1204)

Record as JSON

{
  "id": "MLC-T-CHM-006567",
  "term": "Ligand efficiency",
  "field": "Chemistry",
  "definition": "A metric used in drug discovery to assess the binding affinity of a ligand to its target protein, normalized by the size or complexity of the ligand. It provides a way to compare compounds of different molecular weights or numbers of heavy atoms. This value is often expressed as binding energy per heavy atom or per unit molecular weight.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2016, 88, 239. 'Glossary of terms used in computational drug design, part II (IUPAC Recommendations 2015)' on page 249 (https://doi.org/10.1515/pac-2012-1204)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/ligand-efficiency/"
}

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