Off-rate

{
  "id": "MLC-T-CHM-008201",
  "term": "Off-rate",
  "field": "Chemistry",
  "definition": "The dissociation rate constant (k_off) describing the rate at which a ligand detaches from its binding partner, such as a drug molecule from its receptor. This kinetic parameter quantifies the stability of a molecular complex. A lower off-rate indicates a more stable and longer-lasting interaction between the ligand and its target.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2011, 83, 1129. 'Glossary of terms used in biomolecular screening (IUPAC Recommendations 2011)' on page 1150 (https://doi.org/10.1351/PAC-REC-09-05-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/off-rate/"
}