Phase 0 clinical studies

{
  "id": "MLC-T-CHM-008731",
  "term": "Phase 0 clinical studies",
  "field": "Chemistry",
  "definition": "Exploratory studies conducted early in drug development with very limited human exposure to the investigational drug. These studies involve administering subtherapeutic doses to a small number of subjects to gather preliminary pharmacokinetic and pharmacodynamic data. They are designed to accelerate drug development by identifying promising drug candidates earlier.",
  "synonyms": [
    "exploratory investigational new drug"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "phase I clinical studies",
    "phase II clinical studies",
    "phase III clinical studies",
    "phase IV clinical studies"
  ],
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1746 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/phase-0-clinical-studies/"
}