Philadelphia chromosome

{
  "id": "MLC-T-CHM-008765",
  "term": "Philadelphia chromosome",
  "field": "Chemistry",
  "definition": "A specific chromosomal abnormality resulting from a reciprocal translocation between chromosome 9 and chromosome 22, denoted as t(9;22)(q34;q11). This rearrangement creates a fusion gene, BCR-ABL, which encodes a constitutively active tyrosine kinase. It is a hallmark of chronic myelogenous leukemia (CML) and some acute lymphoblastic leukemias.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "ABL oncogene",
    "chronic myelogenous leukemia"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1228 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/philadelphia-chromosome/"
}