Robertsonian translocation

{
  "id": "MLC-T-CHM-010394",
  "term": "Robertsonian translocation",
  "field": "Chemistry",
  "definition": "A specific type of chromosomal rearrangement that involves the fusion of two acrocentric chromosomes at their centromeres, with the loss of their short arms. This results in a single, larger chromosome and a reduction in the total chromosome number, though the genetic material is largely conserved. It is observed in approximately 1 in 1000 live births.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "chromosomal translocation",
    "acrocentric centromere",
    "karyotype"
  ],
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 801 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/robertsonian-translocation/"
}