Clastogen

{
  "id": "MLC-T-CHM-002104",
  "term": "Clastogen",
  "field": "Chemistry",
  "definition": "An agent or substance that induces structural chromosomal aberrations, such as breaks, deletions, or rearrangements within a cell's genetic material. This damage, known as clastogenesis, results from interactions with DNA that disrupt the physical integrity of the chromosome, leading to fragmented or reconfigured genetic sequences. Unlike aneugens, which alter the total number of chromosomes, clastogens affect the structure of individual chromosomes, with effects detectable by cytogenetic methods like the micronucleus test or chromosomal aberration assay.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 736 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/clastogen/"
}