Spermatogonial chromosome aberration test

{
  "id": "MLC-T-CHM-011179",
  "term": "Spermatogonial chromosome aberration test",
  "field": "Chemistry",
  "definition": "An in vivo genotoxicity assay in which rodents are dosed with a test substance and spermatogonia are later examined at metaphase for structural chromosome aberrations such as breaks and exchanges. It evaluates whether a chemical can damage the chromosomes of male germ cells, a route to heritable genetic effects. Results are given as the percentage of metaphase cells carrying aberrations, compared with concurrent controls, and the method is standardised as OECD Test Guideline 483.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "germ line cell"
  ],
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 807 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/spermatogonial-chromosome-aberration-test/"
}