Classical pathway

{
  "id": "MLC-T-CHM-002103",
  "term": "Classical pathway",
  "field": "Chemistry",
  "definition": "One of the three main routes by which the complement system, a part of the innate immune system, is activated. This pathway is typically initiated by the binding of C1 complex to antibody-antigen complexes or directly to certain microbial surfaces. Its activation leads to a cascade of protein cleavages, ultimately forming the membrane attack complex that lyses target cells.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "alternative pathway"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1144 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/classical-pathway/"
}