Mannan-binding lectin-associated serine peptidase-1 and -2

{
  "id": "MLC-T-CHM-006949",
  "term": "Mannan-binding lectin-associated serine peptidase-1 and -2",
  "field": "Chemistry",
  "definition": "Proteolytic enzymes (MASP-1 and MASP-2) that are components of the lectin pathway of the complement system, a part of the innate immune response. These enzymes become activated upon binding of mannan-binding lectin (MBL) to pathogen surfaces, initiating a cascade of protein cleavages. MASP-2 specifically cleaves C4 and C2, leading to the formation of the C3 convertase.",
  "synonyms": [
    "mannose-binding protein-associated serine protease (MASP)"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "chemotype",
    "mannose-binding protein"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1209 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/mannan-binding-lectin-associated-serine-peptidase-1-and-2/"
}