ABL oncogene

{
  "id": "MLC-T-CHM-000039",
  "term": "ABL oncogene",
  "field": "Chemistry",
  "definition": "A proto-oncogene that encodes a non-receptor tyrosine kinase, involved in cell growth, differentiation, and apoptosis. Chromosomal translocations involving ABL1, such as the Philadelphia chromosome, lead to the formation of fusion proteins with dysregulated kinase activity. This aberrant activity is a hallmark of chronic myelogenous leukemia and some acute lymphoblastic leukemias.",
  "synonyms": [
    "BCR-ABL"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "Philadelphia chromosome",
    "chronic myelogenous leukemia",
    "tyrosine kinase"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1115 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/abl-oncogene/"
}