Target validation

{
  "id": "MLC-T-CHM-011821",
  "term": "Target validation",
  "field": "Chemistry",
  "definition": "The process of confirming that a specific molecular target is involved in a disease process and that modulating its activity will produce a desired therapeutic effect. This involves demonstrating a causal link between the target and the disease phenotype. It is a key step in drug discovery to reduce the risk of late-stage clinical trial failures.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "molecular target"
  ],
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1752 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/target-validation/"
}