Acetylcholinesterase

{
  "id": "MLC-T-CHM-000125",
  "term": "Acetylcholinesterase",
  "field": "Chemistry",
  "definition": "An enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This action terminates the signal at cholinergic synapses and neuromuscular junctions, allowing the neuron or muscle fiber to repolarize. Its activity is irreversibly inhibited by organophosphate compounds, such as certain pesticides and nerve agents, leading to toxic accumulation of acetylcholine.",
  "synonyms": [
    "acetylcholine hydrolase",
    "cholinesterase inhibitor"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "acetylcholine"
  ],
  "references": [
    "PAC, 2015, 87, 841. 'IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)' on page 843 (https://doi.org/10.1515/pac-2015-0103)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/acetylcholinesterase/"
}