Antineutrophil cytoplasmic autoantibody associated vasculitis

{
  "id": "MLC-T-CHM-000700",
  "term": "Antineutrophil cytoplasmic autoantibody associated vasculitis",
  "field": "Chemistry",
  "definition": "A group of autoimmune diseases characterized by inflammation of small blood vessels, driven by the presence of antineutrophil cytoplasmic autoantibodies (ANCAs). These conditions include granulomatosis with polyangiitis (Wegener's), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis. The ANCAs activate neutrophils, leading to endothelial damage and tissue injury.",
  "synonyms": [
    "ANCA-associated vasculitis"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "Wegener granulomatosis",
    "antineutrophil cytoplasmic autoantibody",
    "autoimmune",
    "microscopic polyangiitis",
    "systemic"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1126 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/antineutrophil-cytoplasmic-autoantibody-associated-vasculitis/"
}