Proteinase 3

{
  "id": "MLC-T-CHM-009589",
  "term": "Proteinase 3",
  "field": "Chemistry",
  "definition": "A serine proteinase found primarily in the azurophilic granules of neutrophils, a type of white blood cell. This enzyme contributes to the degradation of extracellular matrix components and the killing of phagocytosed microorganisms. Autoantibodies against proteinase 3 are associated with certain autoimmune diseases, particularly granulomatosis with polyangiitis (Wegener's granulomatosis).",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "Wegener granulomatosis",
    "antineutrophil cytoplasmic autoantibody",
    "autoantibody",
    "autoimmune",
    "monocyte",
    "neutrophil",
    "systemic"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1236 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/proteinase-3/"
}