Microscopic polyangiitis

{
  "id": "MLC-T-CHM-007359",
  "term": "Microscopic polyangiitis",
  "field": "Chemistry",
  "definition": "A systemic autoimmune disease characterized by necrotizing vasculitis, an inflammation that damages the walls of small blood vessels like capillaries, venules, and arterioles. The condition primarily affects the kidneys, causing glomerulonephritis, and the lungs, causing pulmonary capillaritis. A frequent diagnostic marker for this disease is the presence of antineutrophil cytoplasmic autoantibodies (ANCAs), particularly those targeting the enzyme myeloperoxidase (MPO-ANCA).",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "antineutrophil cytoplasmic autoantibody",
    "alveolitis",
    "autoantibody",
    "glomerulonephritis",
    "myeloperoxidase",
    "pauci-immune",
    "vasculitis"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1213 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/microscopic-polyangiitis/"
}